Critical Care, Sepsis, Quality Improvement

9/83 – 6/87 B.A., Harvard University, Cambridge, MA

9/87 – 6/91 M.D., Northwestern University Medical School, Chicago, IL

9/96 – 12/97 M.P.H., University of Michigan School of Public Health

7/91 – 6/94 Residency, University of Michigan Medical Center, Ann Arbor, MI

6/94 – 6/97 Fellowship, University of Michigan Medical Center, Ann Arbor, MI

7/97 – 4/98 Lecturer, University of Michigan Medical Center, Ann Arbor, MI

7/98 – 12/04 Clinical Assistant Professor, Case Western Reserve University
Department of Internal Medicine, Cleveland, Ohio

8/06 – 8/07 Faculty Chairperson, Institute for Healthcare Improvement
Mortality Community, Cambridge, Massachusetts

4/07 – 12/08 Associate Division Head,
Pulmonary, Critical Care, Allergy, Immunology, Sleep Medicine and Research,
Henry Ford Health System, Detroit, Michigan

5/07 – 7/08 Expert Advisory Panel Member,
Eliminating Codes and Associated Mortality on Inpatient Units,
Child Health Corporation of America, Kansas City, MS

8/07 – present Faculty Co-Chairperson, Institute for Healthcare Improvement
Improving Care for High Risk and Critically Ill Patients Community,
Cambridge, Massachusetts

8/07 – 12/08 Clinical Associate Professor, Department of Internal Medicine,
Wayne State University School of Medicine, Detroit, MI

01/09 – present Associate Professor, Department of Internal Medicine,
Wayne State University School of Medicine, Detroit MI

Original observations in refereed journals:

1. DiGiovine B, Lynch JP, Martinez FJ, Flint A, Whyte RI, Iannettoni MD, Arenberg DA, Burdick MD, Glass MC, Wilke CA, Morris SB, Kunkel SL, Strieter RM. Bronchoalveolar lavage neutrophilia is associated with obliterative bronchiolitis after lung transplantation: Role of interleukin-8. The Journal of Immunology, 1996, 157: 4194-4202.

2. Keane MP, Arenberg DA, Lynch JP, Whyte RI, Iannettoni MD, Burdick MD, Wilke CA, Morris SB, Glass MC, DiGiovine B, Kunkel SL, Strieter RM. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. The Journal of Immunology, 1997, 159: 1427-1443.

3. Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Morris SB, Xue YY, Burdick MD, Glass MC, Iannettoni MD, Strieter RM. Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. Journal of Clinical Investigation, 1998; 102: 465-472.

4. Ailani RJ, Ravakhah K, DiGiovine B, Jacobsen G, Tun T, Epstein D, West BC. Dyspnea differentiation index: a new method for the rapid separation of cardiac vs. pulmonary dyspnea. Chest, 1999; 116:1100-1104.

5. DiGiovine B, Chenoweth C, Watts C, Higgins M. The attributable mortality and costs of primary nosocomial bloodstream infections in the Intensive Care Unit. American Journal of Respiratory and Critical Care Medicine, 1999; 160:976-981.

6. Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Strom SRB, Burdick MD, Iannettoni MD, Strieter RM. Macrophage infiltration in human non small cell lung cancer: the role of CC chemokines. Cancer Immunology and Immunotheraoy 2000; 49(2): 63 70.

7. Belpario JA, DiGiovine B, Keane MP, Burdick MD, Xue YY, Ross DJ, Lynch JP, Kunkel SL, Strieter RM. Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. Transplantation, 2002; 73: 591-599.

8. Remington TL, Haeberlin AM, DiGiovine B. Combined Budesonide/Formoterol Turbuhaler Treatment of Asthma. The Annals of Pharmacotherapy 2002; 36(12): 1918-28.

9. Ailani RJ, Alimchandani A, Hidalgo J, Ailani R, Buckley J, DiGiovine B. Cephalosporin resistant pneumococcal pneumonia: Does it affect outcome? Respiratory Medicine 2002; 96: 805-811.

10. Bossone E, DiGiovine B, Watts S, Marcovitz PA, Carey L, Watts C, Armstrong WF. Range and prevalence of cardiac abnormalities in patients hospitalized in a medical ICU. Chest 2002; 122: 1370-1376.

11. Quefatieh A. Stone CH. DiGiovine B. Toews GB. Hyzy RC. Low hospital mortality in patients with acute interstitial pneumonia. Chest 2003; 124(2):554-9.

12. Remington TL, DiGiovine B. Long-acting beta-agonists: anti-inflammatory properties and synergy with corticosteroids in asthma. Current Opinion in Pulmonary Medicine 2005; 11(1): 74-8.

13. McCann J, Artinian V, Duhaime L, Lewis JW, Kvale PA, DiGiovine B. Evaluation of the causes for racial disparity in surgical treatment of early-stage lung cancer. Chest 2005; 128(5): 3440-3446.

14. Artinian V, Krayem H, DiGiovine B. Effects of Early Enteral Feeding on the Outcome of Critically Ill Mechanically Ventilated Medical Patients. Chest 2006; 129(4): 960-967.

15. Mailey J, DiGiovine B, Baillod D, Gnam G, Jordan J, Rubinfeld I, Reducing Hospital Standardized Mortality Rate with Early Interventions. Journal of Trauma Nursing 2006; 13(4): 178-182.

16. Betensley AD, Khalid I, Crawford J, Pensler RA, DiGiovine B, Patient Comfort During Pressure Support and Volume Controlled-Continuous Mandatory Ventilation. Respiratory Care 2008; 53(7):897–902.

17. Khalid I, Khalid TJ, DiGiovine B. A patient with an uncommon complication from insertion of a central venous catheter: A case report. Cases Journal 2008;1(1):353.

Books and chapters:

DiGiovine B, Kelley M. Decision Making in the Intensive Care Unit. Fishman’s Pulmonary Diseases and Disorders, Fourth Edition, 2008, McGraw Hill, New York, NY.

Strieter RM , DiGiovine B, Polverini PJ, Kunkel SL, Shanafelt A, Hesselgesser J, Horuk R, Arenberg DA. CXC chemokines and lung cancer angiogenesis. Chemokines and Cancer, edited by Barrett J Rollins, M.D., Ph.D., Humana Press, Totowa, NJ.