School of Medicine

Wayne State University School of Medicine

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Lobelia Samavati, MD, FCCP
Associate Professor, Research Educator
Director, Sarcoidosis/ILD Center
Full Time
Medical Fellow/Resident/Student Instruction

Harper University Hospital
3990 John R - 3 Hudson
Detroit, MI 48201

(313) 745-1718
Clinical Interests

 Sarcoidosis

Education

04/86-11/92 Medical School at the University of Cologne, Germany
(Combined undergraduate and graduate medical school program)
Received Medical Degree November 1992
 

Post Graduate Training

10/91-02/92 Internal Medicine, Withington & Christie Hospital, University Hospitals of
South Manchester, Manchester, United Kingdom
 
02/92-06/92 General Surgery, Orthopedic Surgery, Plastic and Thoracic Surgery, City
Hospital Cologne-Merheim, Teaching Hospital of the University of Cologne,
Germany
 
06/92-09/92 Neurology, City Hospital Cologne-Merheim, Teaching Hospital of the
University of Cologne, Germany

Residency

07/96-07/99 Internal Medicine, Michael Reese Hospital and Medical Center, University
of Illinois at Chicago, Chicago, Illinois
 
04/93-10/94 Internal Medicine & Rheumatology, State Clinic for Rheumatology,
Aachen, Germany

Fellowship

07/99-07/02 Pulmonary and Critical Care, University of Iowa Hospitals and Clinics,
Iowa City, Iowa , USA   

 

Faculty Appointments

10/04 � Present
Assistant Professor
Pulmonary, Critical Care and Sleep Medicine
Detroit Medical Center
Detroit, Michigan
 
06/03-01/04
Pulmonary Physician
Pulmonary and Critical Care
Central Hospital
Bad Berka, Germany

Research

ONGOING RESEARCH:
 

10/04-present   Basic research in collaboration with the laboratory of Drs. Grossman/H�ttemann. Topic: Effect of Inflammation (TNF α) on cellular respiration and Cytochrome C oxidase  

10/04-present Quality of Life in Patients with Sarcoidosis
IRB approval December 2005
IRB extended until December 2008
Completed enrollment

10/06-present   Study of Predictors of Pulmonary Hypertension in Sarcoidosis

                                 IRB approval since November 2008

07/07-present   Sarcoidosis, Hepatitis C and Interferon-alpha treatment of Hepatitis C (IRB approval since 07/07)

02/07-present   Pharmacokinetics of Fondaparinux in Critically Ill Patients in a Medical Intensive Care Unit (MICU) Investigator initiated research

09/07-present   A phase IIb randomized, double-blind, parallel group, multi-center study to assess the efficacy and safety of multiple 30 minute infusions of Conivaptan in subjects with hypervolemic hyponatremia

04/08-present       Genetic Protein Markers for Sarcoidosis (Crypyrine and NOD Polymorphism) and Their Roles in Innate Immunity

                                 (IRB since 04/08-04/09)

07/00-07/02 Basic research in the laboratory of Dr. Hunninghake

Topic: Oxidant mediated cell signaling.

1989-91   Experimental research at the Institute of Clinical Chemistry of the University of Cologne with Prof. Dr. Karl Oette

Topic: Restriction Fragment Length Polymorphism of Hydroxy-methyl Co-A Reductase gene in patients with Familial Hypercholesterolemia Type IIa

 
GRANTS:
 

02/07-present   Pharmacokinetics of Fondaparinux in Critically Ill Patients in a Medical Intensive Care Unit (MICU) Investigator initiated research (80K Grant from GSK)

09/07-present   A phase IIb randomized, double-blind, parallel group, multi-center study to assess the efficacy and safety of multiple 30 minute infusions of Conivaptan in subjects with hypervolemic hyponatremia (sponsored by Astellas Pharma INC, IRB approval since 09/07 completed) 

Peer-Reviewed Publications

PubMed      GoogleScholar


1. Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCary, PB Jr, Ritchie TC, Hunninghake GW, Zandi E, Engelhardt JF.
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem 2001; 276 (32): 30188-98.

2. Samavati L, Monick MM, Sanlioglu S, Buettner GR, Oberley LW, Hunninghake G.
Mitochondrial K-ATP channel openers activate the ERK kinase by an oxidant dependent mechanism. Am J Physiol Cell Physiol 2002; 283(1): C273-81

3. Samavati L, Monick MM, Butler NS, Mohning M, Powers L, Yarovinsky T, Spitz DR, Hunninghake G W.
Intracellular thiols contribute toTH2 Function via a positive role on IL-4 production. J Immunol 2003; 171(10): 5107-15

4. H�ttemann M, Lee I, Samavati L, Yu H, and Doan JW.
Regulation of the mitochondrial oxidative phosphorylation machinery through cell signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1783, Issue 1, Pages 1-168. January 2008

5. Bourbonnais J M and Samavati L.
Clinical Predictors in Pulmonary Hypertension in Sarcoidosis. European Respiratory Journal, 2008 Aug;32 (2):296-302

6. Samavati L, Lee I, Mathes I, Lottspeich F, and H�ttemann M.
TNFα Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of Cytochrome c Oxidase. Journal of Biological Chemistry 2008 Jul 25;283(30):21134-44

7. Malaisamy S, Bourbonnais J M, Dalal B, Samarakoon P , Parikh S, Smith-Cobb P and Samavati L
Distance Saturation Product Predicts Health Related Quality of Life of Patients with Sarcoidosis (Manuscript submitted)

8- L. Samavati, Ruchi Rastogi, Wenjin Du, Maik H�ttemann, Luigi Franchi, and Gabriel Nuňez
STAT3 Tyrosine Phosphorylation Is Critical for Interleukin 1-beta andInterleukin-6 Production In Response to Lipopolysaccharide and Live Bacteria (Manuscript submitted)